Measuring the Effects of Artificial Viscosity in SPH Simulations of Rotating Fluid Flows

A commonly cited drawback of SPH is the introduction of spurious shear viscosity by the artificial viscosity term in situations involving rotation. Existing approaches for quantifying its effect include approximate analytic formulae and disc-averaged be- haviour in specific ring-spreading simulations, based on the kinematic effects produced by the artificial viscosity. These methods have disadvantages, in that they typically are applicable to a very small range of physical scenarios, have a large number of simplifying assumptions, and often are tied to specific SPH formulations which do not include corrective (e.g., Balsara) or time-dependent viscosity terms. In this study we have developed a simple, generally applicable and practical technique for evaluating the local effect of artificial viscosity directly from the creation of specific entropy for each SPH particle. This local approach is simple and quick to implement, and it al- lows a detailed characterization of viscous effects as a function of position. Several advantages of this method are discussed, including its ease in evaluation, its greater accuracy and its broad applicability. In order to compare this new method with ex- isting ones, simple disc flow examples are used. Even in these basic cases, the very roughly approximate nature of the previous methods is shown. Our local method pro- vides a detailed description of the effects of the artificial viscosity throughout the disc, even for extended examples which implement Balsara corrections. As a further use of this approach, explicit dependencies of the effective viscosity in terms of SPH and flow parameters are estimated from the example cases. In an appendix, a method for the initial placement of SPH particles is discussed which is very effective in reducing numerical fluctuations.Comment: 15 pages, 9 figures, resubmitted to MNRA

Multi-segment foot kinematics and plantar fascia strain during treadmill and overground running

Although physiologically beneficial, running is known to be associated with a high incidence of chronic injuries. Excessive coronal and transverse plane motions of the foot segments and strain experienced by the plantar fascia are linked to the development of a number of chronic injuries. This study examined differences in multi-segment foot kinematics and plantar fascia strain during treadmill and overground running. Twelve male recreational runners ran at 4.0 m.s-1 in both treadmill and overground conditions. Multi-segment foot kinematics and plantar fascia strain were measured using an eight-camera motion analysis system and contrasted using paired samples t-tests. The results showed that plantar fascia strain was significantly greater in the overground condition (8.23 ± 2.77) compared to the treadmill (5.53 ± 2.25). Given the proposed relationship between excessive plantar fascia strain and the etiology of injury, overground running may be associated with a higher incidence of injury although further work is necessary before causation can be confirmed

Effects of new military footwear on knee loading during running

Military recruits are known to be susceptible to chronic injuries. The knee is the most common injury site and patellofemoral pain has been demonstrated as the leading mechanism for medical military discharge. Military boots have been cited as a key mechanism responsible for the high incidence of chronic injuries. The British Army has therefore introduced two new footwears – a cross-trainer and running shoe to reduce the incidence of chronic injuries. The aim of this study was to compare knee joint kinetics of the cross-trainer and running shoe in relation to conventional military boots. Twelve male participants ran at 4.0 m s−1 in each footwear condition. Knee joint kinetics was obtained and contrasted using repeated-measures ANOVAs. The results showed that patellofemoral load was significantly greater in the military boots. However, peak knee abduction moment was significantly greater in the running shoes. On the basis of the findings from this study, it is recommended that recruits who are susceptible to injuries mediated through excessive knee loads select the cross-trainer for their running activities

The Effects of Barefoot and Shod Running on Limb and Joint Stiffness Characteristics in Recreational Runners.

The authors aimed to determine the effects of barefoot (BF) and several commercially available barefoot-inspired (BFIS) footwear models on limb and joint stiffness characteristics compared with conventional footwear (CF). Fifteen male participants ran over a force platform at 4.0 m.s-1, in BF, BFIS, and CF conditions. Measures of limb and joint stiffness were calculated for each footwear. The results indicate that limb and knee stiffness were greater in BF and minimalist BFIS than in CF. CF and more structured BFIS were associated with a greater ankle stiffness compared with BF and minimalist BFIS. These findings serve to provide further insight into the susceptibility of runners to different injury mechanisms as a function of footwear

Sex differences in limb and joint stiffnes in recreational runners

Purpose. Female runners are known to be at greater risk from chronic running injuries than age-matched males, although the exact mechanisms are often poorly understood. The aim of the current investigation was to determine if female recreational runners exhibit distinct limb and joint stiffness characteristics in relation to their male counterparts. Methods. Fourteen male and fourteen female runners ran over a force platform at 4.0 m · s–1. Lower limb kinematics were collected using an eight-camera optoelectric motion capture system operating at 250 Hz. Measures of limb and joint stiffness were calculated as a function of limb length and joint moments divided by the extent of limb and joint excursion. All stiffness and joint moment parameters were normalized to body mass. Sex differences in normalized limb and knee and ankle joint stiffness were examined statistically using independent samples t tests. Results. The results indicate that normalized limb (male = 0.18 ± 0.07, female = 0.37 ± 0.10 kN · kg · m–1) and knee stiffness (male = 5.59 ± 2.02, female = 7.34 ± 1.78 Nm · kg · rad–1) were significantly greater in female runners. Conclusions. On the basis that normalized knee and limb stiffness were shown to be significantly greater in female runners, the findings from the current investigation may provide further insight into the aetiology of the distinct injury patterns observed between sexes

Computerized crime linkage systems: A critical review and research agenda

Computerized crime linkage systems are meant to assist the police in determining whether crimes have been committed by the same offender. In this article, the authors assess these systems critically and identify four assumptions that affect the effectiveness of these systems. These assumptions are that (a) data in the systems can be coded reliably, (b) data in the systems are accurate, (c) violent serial offenders exhibit consistent but distinctive patterns of behavior, and (d) analysts have the ability to use the data in the systems to link crimes accurately. The authors argue that there is no compelling empirical support for any of the four assumptions, and they outline a research agenda for testing each assumption. Until evidence supporting these assumptions becomes available, the value of linkage systems will remain open to debate

Influence of minimalist footwear on knee and ankle loads during the squash lunge

Squash is associated with a high incidence of knee and ankle joint injuries. The aim of this work was to examine the effects of squash specific, running shoes and minimalist footwear on knee and ankle loads during the lunge movement in squash players. Twelve male squash players performed lunge movements whilst wearing squash specific, running shoes and minimalist footwear. The loads experienced by the knee and ankle joints were calculated. Patellofemoral forces were significantly greater in running shoes (5.10 B.W) compared to minimalist footwear (4.29 B.W). Achille tendon forces were significantly larger in the minimalist footwear (3.10 B.W) compared to the running shoes (2.64 B.W) and squash specific footwear (2.88 B.W). This shows that whilst minimalist footwear may reduce the incidence of knee pathologies in squash players corresponding increases in ankle loading may induce an injury risk at this joint

A spatial covariance (123)I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer's disease

Alzheimer's disease (AD) is characterized by widespread degeneration of cholinergic neurons, particularly in the basal forebrain. However, the pattern of these deficits and relationship with known brain networks is unknown. In this study, we sought to clarify this and used 123I-5-iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (1235IA-85380) single photon emission computed tomography to investigate spatial covariance of α4β2 nicotinic acetylcholine receptors in AD and healthy controls. Thirteen AD and 16 controls underwent 1235IA-85380 and regional cerebral blood flow (99mTc-exametazime) single photon emission computed tomography scanning. We applied voxel principal component (PC) analysis, generating series of principal component images representing common intercorrelated voxels across subjects. Linear regression generated specific α4β2 and regional cerebral blood flow covariance patterns that differentiated AD from controls. The α4β2 pattern showed relative decreased uptake in numerous brain regions implicating several networks including default mode, salience, and Papez hubs. Thus, as well as basal forebrain and brainstem cholinergic system dysfunction, cholinergic deficits mediated through nicotinic acetylcholine receptors could be evident within key networks in AD. These findings may be important for the pathophysiology of AD and its associated cognitive and behavioral phenotypes

Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias?

INTRODUCTION: Two methods of non-invasive brain stimulation, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have demonstrable positive effects on cognition and can ameliorate neuropsychiatric symptoms such as depression. Less is known about the efficacy of these approaches in common neurodegenerative diseases. In this review, we evaluate the effects of TMS and tDCS upon cognitive and neuropsychiatric symptoms in the major dementias, including Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), Parkinson's disease with dementia (PDD), and frontotemporal dementia (FTD), as well as the potential pre-dementia states of Mild Cognitive Impairment (MCI) and Parkinson's disease (PD). METHODS: PubMed (until 7 February 2014) and PsycINFO (from 1967 to January Week 3 2014) databases were searched in a semi-systematic manner in order to identify relevant treatment studies. A total of 762 studies were identified and 32 studies (18 in the dementias and 14 in PD populations) were included. RESULTS: No studies were identified in patients with PDD, FTD or VaD. Of the dementias, 13 studies were conducted in patients with AD, one in DLB, and four in MCI. A total of 16 of the 18 studies showed improvements in at least one cognitive or neuropsychiatric outcome measure. Cognitive or neuropsychiatric improvements were observed in 12 of the 14 studies conducted in patients with PD. CONCLUSIONS: Both TMS and tDCS may have potential as interventions for the treatment of symptoms associated with dementia and PD. These results are promising; however, available data were limited, particularly within VaD, PDD and FTD, and major challenges exist in order to maximise the efficacy and clinical utility of both techniques. In particular, stimulation parameters vary considerably between studies and are likely to subsequently impact upon treatment efficacy

Personalized medicine : the impact on chemistry

An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift, that of network pharmacology. We examine the intersection of personalized medicine and network pharmacology to identify strategies for the development of personalized therapies that are fully informed by network pharmacology concepts. This provides a framework for discussion of the impact personalized medicine will have on chemistry in terms of drug discovery, formulation and delivery, the adaptations and changes in ideology required and the contribution chemistry is already making. New ways of conceptualizing chemistry’s relationship with medicine will lead to new approaches to drug discovery and hold promise of delivering safer and more effective therapies